Endocrine Abstracts

Introduction: Li-Fraumeni syndrome is a rare disorder that greatly increases the risk of developing several types of cancer, particularly in children and young adults. It is a hereditary disease with high penetrance autosomal dominant transmission that is due, in 70% of the cases, to germline mutations in the gene TP53. The most common cancers associated with this disorder are brain tumors, sarcomas, breast cancer and adrenocortical tumors.Methods: We de...